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Microneedle‐assisted transdermal delivery of nanoparticles: …
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Effects of Histidine and Sucrose on the Biophysical Properties of a …
Example of A6 synthesis route was shown in Supplementary Fig. 30, where the diacid 4 was synthesized as reported by Maier et al.11 previously. The last esterification step was also followed by the method reported by Maier et al.11. The distinct steps for all alkyne lipids (A1–A6) were described as below: Synthesis … See more mRNA was synthesized by Translate Bio®using T7 RNA polymerase-mediated transcription from a linearized DNA template, which incorporates the 5ʹ and 3ʹ untranslated regions (UTRs), and a poly(A) tail (no nucleotide … See more All experiments were conducted four times to ensure reproducibility. LNP suspensions were incubated with an equal amount of mouse serum for 1 h at 37 °C (total volume of 350 μL). The serum coated LNPs were … See more Lipid nanoparticles (LNPs) were prepared by mixing an ethanol phase containing lipids with mRNA in an aqueous phase in a microfluidic chip … See more The apparent pKa of each cationic lipid was determined using a fluorescent probe 2-(p-toluidino)-6-napthalene sulfonic acid (TNS) and preformed LNPs composed of cationic … See more WebMay 24, 2024 · Purpose: To investigate differences in the preferential exclusion of trehalose, sucrose, sorbitol and mannitol from the surface of three IgG1 monoclonal antibodies … WebDec 16, 2024 · Strategic Alliance: A strategic alliance is an arrangement between two companies that have decided to share resources to undertake a specific, mutually beneficial project. A strategic alliance is ... cheap shipping for moving