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Hotair overexpression

WebApr 3, 2024 · The transport of multivesicular bodies (MVBs) after overexpression of HOTAIR was detected by transmission electron microscopy and confocal microscopy analysis of cluster determinant 63 (CD63) with synaptosome associated protein 23 (SNAP23). The mechanism of HOTAIR’s regulation of Ras-related protein Rab-35 (RAB35), vesicle … WebHOTAIR was the first lncRNA to be identified for its role in metastasis. Overexpression of HOTAIR is associated with metastasis in multiple cancers, including breast, pancreatic, …

HOTAIR - an overview ScienceDirect Topics

WebNon-coding RNAs are emergent elements from the genome, which do not encode for proteins but have relevant cellular functions impacting almost all the physiological processes occurring in eukaryotic cells. In particular, microRNAs and long non-coding RNAs (lncRNAs) are a new class of small RNAs transcribed from the genome, which modulate … WebApr 12, 2024 · Carolina BalloonFest is the second-oldest hot air balloon festival in the world and been running for nearly 50 years. The Statesville -based festival brings in close to … small standalone cabinet for bathroom https://telefoniastar.com

Inducible lncRNA transgenic mice reveal continual role of HOTAIR …

WebNext, HOTAIR overexpression was transfected into H9c2 cells and exposed to H/R. qRT-PCR results showed that HOTAIR overexpression attenuated the up-regulation of miR-17-5p expression induced by H/R . Western blot verified that HOTAIR overexpression partially reversed H/R-induced down-regulation of p-STAT3 expressions ( Figure 4B and C ). WebFeb 7, 2024 · Downregulation of HOTAIR was detected in osteosarcoma, which predicted poor prognosis of patients with osteosarcoma. Moreover, cell migration, invasion, and proliferation were suppressed by HOTAIR overexpression in osteosarcoma. Furthermore, LPR5 was a direct target of HOTAIR, which was upregulated in osteosarcoma. WebApr 15, 2010 · Conversely, overexpression of EZH2 in H16N2 breast cells is known to promote matrix invasion 12, but concomitant depletion of endogenous HOTAIR in large … highway alliance

The Long Noncoding RNA Hotair Regulates Oxidative Stress and ... - Hindawi

Category:Functions and underlying mechanisms of lncRNA HOTAIR in …

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Hotair overexpression

PRC2 is dispensable for HOTAIR‐mediated transcriptional …

WebMar 30, 2024 · BisPhenol A, diethylstilbesterol, and IRF1 promote the overexpression of HOTAIR by binding to the corresponding gene promoter elements. Bisphenol A and diethylstilbesterol independently interact with estrogen receptors in the cytoplasm, translocate into the nucleus, associate with the methyl transferases MLL1 and MLL3, bind … WebMay 21, 2015 · Effects of HOTAIR overexpression differed between cell lines. Whereas VM-CUB1 cells acquired the expected phenotype with increased proliferation, clonogenicity, …

Hotair overexpression

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WebSep 13, 2024 · Overexpression of HOTAIR increased the expression of CSC-related biomarkers and was correlated with Klf4 expression, which could be used as a promising … WebJul 15, 2024 · HOTAIR is a long noncoding RNA (lncRNA) which serves as an important factor regulating diverse processes linked with cancer development. Here, we used comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) to explore the HOTAIR-protein interactome. We were able to identify 348 proteins interacting …

WebDec 6, 2024 · HOTAIR overexpression enhanced, whereas its knockdown reduced, cell proliferation, cachexia-associated pro-inflammatory cytokine expression, and muscle atrophy. Cachexia-associated symptoms were ameliorated in mice bearing Hotair-knockdown bladder tumors undergoing cisplatin treatment. We demonstrate for the first …

WebOverexpression of HOTAIR (HOX antisense intergenic RNA) is significantly correlated with tumor progression and poor prognosis in human ovarian cancer. However, the underlying mechanisms are largely unknown. In the present study, we investigated the roles of HOTAIR in the initiation and chemoresistan … WebSep 13, 2024 · Overexpression of HOTAIR increased the expression of CSC-related biomarkers and was correlated with Klf4 expression, which could be used as a promising therapeutic target. A year later, another ...

WebApr 4, 2024 · Moreover, the overexpression of hsa-miR-30a-5p inhibited the expression of GRP78 and PD-L1, but Hotair overexpression in LSCC cells rescues both proteins. Furthermore, the impacts of hsa-miR-30a-5p upregulation on the apoptosis and proliferation of LSCC cells were rescued by overexpression of Hotair. Finally, we combined si-Hotair …

WebMar 30, 2024 · Nevertheless, overexpression of FUS can partially reverse the effect of overexpression of HOTAIR on Cyclin D1 and p21, while overexpression of SIRT3 can … small standing bath towel laddersWebJul 11, 2024 · Overexpression of HOTAIR (HOTAIR OE, presented in figures as HOTAIR clone) and its effect on c-Met expression were analyzed and confirmed with confocal … highway alliance cuWebOct 1, 2024 · Based on the overexpression of HOTAIR in a variety of human cancers, technologies related to its utility as a useful target for early cancer detection and treatment are rapidly developing, such as the liposome-encapsulated antisense oligonucleotide probe 99 m Tc-HYNIC-ASON targeting HOTAIR for its in vivo imaging in malignant GBM … small standing bird bathWebMay 21, 2012 · HOTAIR is a long intervening non-coding RNA (lincRNA) that associates with the Polycomb Repressive Complex 2 (PRC2) and overexpression is correlated with poor survival for breast, colon and liver ... small stand up showersWebNational Center for Biotechnology Information small standard couch dimensionsWebJun 16, 2024 · HOTAIR overexpression has been shown to promote adipogenesis in abdominal adipose stem cells (ASCs) 3 and to prevent adipose differentiation of bone marrow mesenchymal stem cells 7. highway allegible scooter bikeWebApr 28, 2014 · Furthermore, HOTAIR overexpression promoted the proliferation, migration and invasion of gastric carcinoma cells, while HOTAIR depletion inhibited both cell … small standing coat rack