WebCarbonylcyanide-3-chlorophenylhydrazone (CCCP) is a protonophore, which causes uncoupling of proton gradient in the inner mitochondrial membrane, thus inhibiting the rate of ATP synthesis. CCCP inhibits STING-mediated IFN-β production via disrupting mitochondrial membrane potential (MMP). WebOct 21, 2024 · The mobile proton carrier CCCP directly inhibited TbAQP2 glycerol permeability at an IC 50 of 2 µM, and TbAQP3 to a much lesser extent (IC 50 around 1 mM) likely due to different selectivity filter layouts. Nigericin, another mobile carrier, left both isoforms unaffected.
Protonophore - an overview ScienceDirect Topics
WebMar 7, 2016 · In the present study, human glioma (T98G and U-87MG) and prostate cancer (PC-3) cells were titrated with different concentrations of the protonophore CCCP to induce maximal oxygen consumption rate (OCR) within respirometers in … WebWe propose a simple model that accounts for the ability of the weak acid FCCP (Carbonylcyanide-p-trifluoromethoxyphenylhydrazone) to both transport protons across ... indian grocery list in hindi
Effects of the protonophore carbonyl-cyanide m ... - ScienceDirect
WebCarbonyl Cyanide m-Chlorophenylhydrazone, CAS 555-60-2, is a protonophore uncoupling agent for oxidative phosphorylation. Shown to be about 100-fold more effective than 2, 4-DNP. MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. SDS CoA References Data Sheet Synonyms: CCCP WebApr 3, 2024 · The CCCP (carbonyl cyanide m-chlorophenylhydrazone) method 23-25 or MBE method (as renamed recently) 26 was used for the monitoring of membrane potential evolution. Briefly, when RBCs are suspended in nominally buffer-free solution in the presence of the CCCP protonophore (10 μM), changes in extracellular pH reflect … WebNov 1, 2013 · Depolarization of mitochondria by the protonophore CCCP is a strategy increasingly used to experimentally trigger not only mitophagy, but also bulk autophagy. … local small town seafood dives virginia